Plenty of former Premier League players for Roma as they look to make a stunning turnaround.
Ex-Spurs defender Federico Fazio and former Manchester City players Aleksandar Kolarov and Edin Dzeko all start.
Roma XI: Allison, Manolas, Fazio, Jesus, Kolarov, Nainggolan, De Rossi, Strootman, Florenzi, Dzeko, Schick.
Barcelona field a strong team in Italy despite their comfortable advantage.
Philippe Coutinho is cup-tied so misses out and there is no Ousmane Dembele either. Lionel Messi leads the line.
Barca XI: Ter Stegen, Semedo, Pique, Umtiti, Alba, Busquets, Rakitic, Iniesta, Roberto, Suarez, Messi.