Both teams are back to full strength after resting players at the weekend – five changes for Liverpool, six for Roma.
Roberto Firmino, Alex Oxlade-Chamberlain and defenders Trent Alexander-Arnold, Dejan Lovren and Andrew Robertson come in for Liverpool. Mohamed Salah and Sadio Mane both played in the 2-2 draw with West Brom and keep their places.
For Roma, ex-Manchester City pair Edin Dzeko and Aleksandar Kolarov start – as do captain Daniele de Rossi, highly rated youngster Cengiz Under and Alessandro Florenzi and Juan Jesus. Liverpool will have to watch all-action midfielder Radja Nainggolan closely – he scored in the 3-0 win over SPAL and starts on the left side of a front three.